Category Archives: Research & Trials

MOLL Feasibility Study with TAKUMI

In a multicenter feasibility study, Matrix Cell Research Insitute Inc.’s magnetic probe TAKUMI was used in conjunction with Hakko Co., Ltd.’s magnetic Guiding-Marker System®, to verify the effectiveness of a magnetic guiding localization system with ultrasound guidance for both detection and excision of non-palpable breast lesions. The article “Magnetically Guided Localization Using a Guiding-Marker System® and… Read More »

CE Marking Expansion to MOLL with TAKUMI

Ongoing research proved that TAKUMI is not only effective in minimally-invasive sentinel lymph node biopsies, but also in magnetically-guided localization of occult lesions (MOLL). Matrix Cell Research Insitute Inc. has therefore added this medical procedure to TAKUMI’s scope of application and expanded the magnetic probe’s CE Marking certificate accordingly. Here are two clinical reports for… Read More »

MR Lymphography of SLN using SPIO

Mikio Shiozawa, from the Department of Surgery at Jichi Medical University, shortly describes a feasibility study on magnetic resonance lymphography of sentinel lymph nodes (SLN) in breast cancer patients using superparamagnetic iron oxide (SPIO): To further advance the SLN biopsy technique using SPIOs, we evaluated preoperative SPIO-MR sentinel lymphography to facilitate accurate identification of the… Read More »

Magnetic Detection of SLN in Veterinary Medicine

Breast cancer is one of the most common tumors not only in humans, but also in dogs. The choice of treatment is also similar: surgical resection and metastatic lymph node removal. In some cases, lymph node mapping can be performed via pre-operative CT examination, however, an intraoperative SLN identification method has yet to be established… Read More »

The Hall Sensor – A Key Component of TAKUMI

The second key component of TAKUMI, the magnetic probe for sentinel lymph node identification, is a Hall sensor. Why choose a Hall sensor over other high precision magnetic flux sensors? The reason for that is the permanent magnet. The magnetic sensor has to be positioned at a specific point: on the center axis of the… Read More »

IOP eBook: Magnetic Nanoparticles for Medical Diagnostics

This publication covers the recent trend towards employing magnetic nanoparticles in a variety of medical applications, aiming to bring professionals in medicine and scientific researchers closer together to further advance and explore the possibilities in this field. Performing sentinel lymph node biopsies by employing magnetic nanoparticles in conjunction with a magnetic probe is the subject… Read More »

Magnetic Tracer Imaging in Laparoscopic Surgery

Drs. Kisyo Mihara and Sachiko Matsuda, lecturers at the Keio University School of Medicine, briefly summarize their presentation of a novel tracer imaging for SLN-navigated laparoscopic surgery in gallbladder cancer during the 74th General Meeting of the Japanese Society of Gastroenterological Surgery Conference (Session title: Significance and future prospects of navigation surgery for hepato-pancreato-biliary surgery, July 28, 2019): “The aim of… Read More »

SLNB in Axillary Lymph Node-Positive Breast Cancer

While sentinel lymph node biopsy (SLNB) of axillary lymph nodes has become standard practice for the staging and treatment in early breast cancer, SLNB of parasternal lymph nodes has yet to be established as a routine performance due to its lack of clinical relevance. Possibly because its effectiveness has only been studied in axillary lymph… Read More »

Clinical Application of TAKUMI

Prof. Masujiro Makita, Head of the Department of Breast Surgery at Nippon Medical School Hospital, elaborates on his experience using TAKUMI in his numerous clinical trials: “I was very intrigued to test how sentinel lymph node biopsy using TAKUMI in conjunction with Ferucarbotran (Resovist®), a superparamagnetic iron oxide contrast agent, would fare against the traditional… Read More »

Ferucarbotran vs. RI/Dye Method

Clinical trials have proven the magnetic fluid method to not be inferior to the radioisotope and dye method in breast cancer SLNB (Taruno K, et al ASCO 2018, J Clin Oncol 36, 2018 suppl:abstr e12603).Since the radioisotope method cannot be performed in many medical facilities in Japan, blue dye, fluorescent dye, or both are often… Read More »