Category Archives: Research & Trials

Magnetic Detection of SLN in Veterinary Medicine

Breast cancer is one of the most common tumors not only in humans, but also in dogs. The choice of treatment is also similar: surgical resection and metastatic lymph node removal. In some cases, lymph node mapping can be performed via pre-operative CT examination, however, an intraoperative SLN identification method has yet to be established… Read More »

The Hall Sensor – A Key Component of TAKUMI

The second key component of TAKUMI, the magnetic probe for sentinel lymph node identification, is a Hall sensor. Why choose a Hall sensor over other high precision magnetic flux sensors? The reason for that is the permanent magnet. The magnetic sensor has to be positioned at a specific point: on the center axis of the… Read More »

IOP eBook: Magnetic Nanoparticles for Medical Diagnostics

This publication covers the recent trend towards employing magnetic nanoparticles in a variety of medical applications, aiming to bring professionals in medicine and scientific researchers closer together to further advance and explore the possibilities in this field. Performing sentinel lymph node biopsies by employing magnetic nanoparticles in conjunction with a magnetic probe is the subject… Read More »

Magnetic Tracer Imaging in Laparoscopic Surgery

Drs. Kisyo Mihara and Sachiko Matsuda, lecturers at the Keio University School of Medicine, briefly summarize their presentation of a novel tracer imaging for SLN-navigated laparoscopic surgery in gallbladder cancer during the 74th General Meeting of the Japanese Society of Gastroenterological Surgery Conference (Session title: Significance and future prospects of navigation surgery for hepato-pancreato-biliary surgery, July 28, 2019): “The aim of… Read More »

SLNB in Axillary Lymph Node-Positive Breast Cancer

While sentinel lymph node biopsy (SLNB) of axillary lymph nodes has become standard practice for the staging and treatment in early breast cancer, SLNB of parasternal lymph nodes has yet to be established as a routine performance due to its lack of clinical relevance. Possibly because its effectiveness has only been studied in axillary lymph… Read More »

Clinical Application of TAKUMI

Prof. Masujiro Makita, Head of the Department of Breast Surgery at Nippon Medical School Hospital, elaborates on his experience using TAKUMI in his numerous clinical trials: “I was very intrigued to test how sentinel lymph node biopsy using TAKUMI in conjunction with Ferucarbotran (Resovist®), a superparamagnetic iron oxide contrast agent, would fare against the traditional… Read More »

Ferucarbotran vs. RI/Dye Method

Clinical trials have proven the magnetic fluid method to not be inferior to the radioisotope and dye method in breast cancer SLNB (Taruno K, et al ASCO 2018, J Clin Oncol 36, 2018 suppl:abstr e12603).Since the radioisotope method cannot be performed in many medical facilities in Japan, blue dye, fluorescent dye, or both are often… Read More »

Development of SLNB using Magnetic Fluid

Mikio Shiozawa, from the Department of Surgery at Jichi Medical University, describes the development of sentinel lymph node biopsy using magnetic fluid (RESOVIST®):“Since around 2007, I had been working at a small community hospital that did not have the facilities to perform the radioisotope method and I was contemplating alternative ways, like using magnetic fluids.… Read More »

SLN Clinical Trial Phase

From 1999 to 2002, a third phase of multicenter clinical trials, focusing on axillary lymph node dissection (ALND), was conducted: randomized comparisons between “ALND vs. omission of ALND” and “ALND vs. radiotherapy” were performed, analyzing their respective disease-free survival rate, overall survival rate and lymph node recurrence rate, including sentinel node-negative and sentinel node-positive cases.The… Read More »

Sentinel Lymph Node Identification

The concept of sentinel lymph nodes (SLN) was introduced in breast cancer treatment in the 1990s. The clinical trials conducted included identification of the sentinel lymph node through injection of radiocolloids and dyes near the tumor, subsequent dissection of the axillary lymph nodes, and examination for metastasis. Furthermore, correlations between presence or absence of metastasis… Read More »